2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140106
    Azido-PEG3-SS-PEG3-azide 1310827-27-0 99.29%
    Azido-PEG3-SS-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-SS-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-SS-PEG3-azide
  • HY-W002886
    N-Boc-cis-4-hydroxy-L-proline 87691-27-8 ≥98.0%
    N-Boc-cis-4-hydroxy-L-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-L-proline is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2
    N-Boc-cis-4-hydroxy-L-proline
  • HY-140925
    Diazo Biotin-PEG3-alkyne 1884349-58-9 98.07%
    Diazo Biotin-PEG3-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Diazo Biotin-PEG3-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Diazo Biotin-PEG3-alkyne
  • HY-129621
    N3-PEG5-C6-Cl 1261238-21-4 99.71%
    N3-PEG5-C6-Cl is a PEG PROTAC linker, can be used for synthesis of HALo PROTAC.
    N3-PEG5-C6-Cl
  • HY-130488
    Hydroxy-PEG2-C2-PFP ester 1820673-42-4
    Hydroxy-PEG2-C2-PFP ester is a PEG/Alkyl/ether-based?PROTAC linker can be used in the synthesis of PROTACs.
    Hydroxy-PEG2-C2-PFP ester
  • HY-77475
    1-Cbz-3-Hydroxyazetidine 128117-22-6 99.89%
    1-Cbz-3-Hydroxyazetidine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Cbz-3-Hydroxyazetidine is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    1-Cbz-3-Hydroxyazetidine
  • HY-140970
    Mal-PEG8-alcohol 2353409-63-7
    Mal-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG8-alcohol
  • HY-140088
    NH-bis(PEG2-propargyl) 2100306-83-8
    NH-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH-bis(PEG2-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    NH-bis(PEG2-propargyl)
  • HY-W108219
    Benzyl-PEG4-Ots 89346-82-7
    Benzyl-PEG4-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Benzyl-PEG4-Ots
  • HY-W042714
    BnO-PEG5-OH 57671-28-0 98.55%
    BnO-PEG5-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    BnO-PEG5-OH
  • HY-W096094
    Fmoc-N-amido-PEG2-alcohol 299430-87-8 99.51%
    Fmoc-N-amido-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-N-amido-PEG2-alcohol
  • HY-140993
    Bis-Mal-PEG3 1008402-47-8
    Bis-Mal-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis-Mal-PEG3
  • HY-140912
    Biotin-PEG11-azide 2276672-04-7 98.0%
    Biotin-PEG11-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG11-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Biotin-PEG11-azide
  • HY-134677
    Bromo-PEG7-Boc 2766000-37-5
    Bromo-PEG7-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG7-Boc
  • HY-130145
    m-PEG8-CH2COOH 102013-72-9 99.88%
    m-PEG8-CH2COOH is a PEG--based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG8-CH2COOH
  • HY-130383
    Propargyl-PEG7-acid 2093154-00-6 ≥98.0%
    Propargyl-PEG7-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG7-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG7-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG7-acid
  • HY-140249
    Tri(Amino-PEG3-amide)-amine 2523025-40-1 98.0%
    Tri(Amino-PEG3-amide)-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tri(Amino-PEG3-amide)-amine
  • HY-130232
    Mal-amido-PEG2-TFP ester 1431291-44-9 98.68%
    Mal-amido-PEG2-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amido-PEG2-TFP ester
  • HY-134745
    DSPE-PEG2-mal 1915739-87-5 99.91%
    DSPE-PEG2-mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    DSPE-PEG2-mal
  • HY-W881439
    1-(1,1-Dimethylethyl) tridecanedioate 2703752-86-5
    1-(1,1-Dimethylethyl) tridecanedioate is a PROTAC Linker and can be used for PROTAC synthesis, such as FF2039 (HY-172159).
    1-(1,1-Dimethylethyl) tridecanedioate
PROTAC Linkers Isoform Comparison

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